Drug interactions
Fenofibrate + Glyburide
Severity: Moderate
Fenofibrate and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may enhance the glucose-lowering effect of sulfonylureas such as glyburide, and hypoglycemia can result. Improved insulin sensitivity with fenofibrate may contribute. Patients with low albumin, renal impairment or erratic intake are at higher risk.
What this interaction means in plain words
Fenofibrate and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Glyburide belongs to Endocrine.
Why it happens
Possible displacement from plasma protein binding combined with additive glucose-lowering pharmacodynamic effects; the evidence for each component is limited.
What to do
Check blood glucose more often after starting or stopping fenofibrate in patients on glyburide. Lower the glyburide dose if hypoglycemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Fenofibrate with Glyburide?
MediHelp rates the interaction as moderate. Fenofibrate and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates may enhance the glucose-lowering effect of sulfonylureas such as glyburide, and hypoglycemia can result. Improved insulin sensitivity with fenofibrate may contribute. Patients with low albumin, renal impairment or erratic intake are at higher risk.
How serious is the interaction between Fenofibrate and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often after starting or stopping fenofibrate in patients on glyburide. Lower the glyburide dose if hypoglycemia appears.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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