Drug interactions
Fenofibrate + Lenacapavir
Severity: Minor
Fenofibrate and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, but fenofibrate is cleared mainly by esterases and glucuronidation, so a clinically important rise in exposure is unlikely.
What this interaction means in plain words
Fenofibrate and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Theoretical CYP3A4 inhibition by lenacapavir with limited relevance to fenofibrate clearance.
What to do
No dose adjustment is needed. Monitor for fenofibrate adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fenofibrate with Lenacapavir?
MediHelp rates the interaction as minor. Fenofibrate and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A4 inhibitor, but fenofibrate is cleared mainly by esterases and glucuronidation, so a clinically important rise in exposure is unlikely.
How serious is the interaction between Fenofibrate and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for fenofibrate adverse effects as usual.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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