Drug interactions
Fenofibrate + Mitotane
Severity: Minor
Fenofibrate and Mitotane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong enzyme inducer and could lower fenofibric acid exposure. Because fenofibrate is not mainly cleared by CYP3A4, the effect is uncertain and probably modest.
What this interaction means in plain words
Fenofibrate and Mitotane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4 and possibly glucuronidation, which may increase fenofibric acid clearance.
What to do
Check the lipid profile after the combination is started and adjust the fenofibrate dose if the response falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Fenofibrate with Mitotane?
MediHelp rates the interaction as minor. Fenofibrate and Mitotane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mitotane is a strong enzyme inducer and could lower fenofibric acid exposure. Because fenofibrate is not mainly cleared by CYP3A4, the effect is uncertain and probably modest.
How serious is the interaction between Fenofibrate and Mitotane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after the combination is started and adjust the fenofibrate dose if the response falls.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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