Drug interactions
fenofibrate + valproic acid
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Increased risk of hepatotoxicity; both agents can elevate transaminases and rarely cause serious liver injury.
Mechanism of action
Additive hepatotoxic potential; possible increase in free valproate due to protein-binding displacement (clinical significance uncertain).
Clinical management
Obtain baseline and periodic LFTs; avoid in active liver disease; counsel on symptoms (fatigue, jaundice, abdominal pain); discontinue one or both if significant LFT elevation or hepatotoxicity signs occur.
Drug reference
References
- Fenofibrate Prescribing Information — Liver function monitoring and hepatotoxicity — FDA Label
- Valproate (divalproex/valproic acid) Prescribing Information — Hepatic failure and liver function monitoring — FDA Label
- Fenofibrate — Drug interactions (use with other hepatotoxic agents) — Lexicomp
Frequently asked questions
Can I take fenofibrate with valproic acid?
The interaction is rated: Moderate. Increased risk of hepatotoxicity; both agents can elevate transaminases and rarely cause serious liver injury.
How serious is the interaction between fenofibrate and valproic acid?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between fenofibrate and valproic acid managed?
Obtain baseline and periodic LFTs; avoid in active liver disease; counsel on symptoms (fatigue, jaundice, abdominal pain); discontinue one or both if significant LFT elevation or hepatotoxicity signs occur.
Why do fenofibrate and valproic acid interact?
Additive hepatotoxic potential; possible increase in free valproate due to protein-binding displacement (clinical significance uncertain).
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