Drug interactions
Fenofibrate + Warfarin
Severity: Moderate
Fenofibrate and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate can enhance warfarin effect and raise INR, increasing bleeding risk. The effect is usually manageable with dose reduction and monitoring.
What this interaction means in plain words
Fenofibrate and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Probable inhibition of CYP2C9 metabolism of warfarin, possibly with protein-binding displacement.
What to do
Check INR more often when starting or stopping fenofibrate and reduce the warfarin dose as needed. Continue monitoring until INR is stable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Warfarin?
MediHelp rates the interaction as moderate. Fenofibrate and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibrate can enhance warfarin effect and raise INR, increasing bleeding risk. The effect is usually manageable with dose reduction and monitoring.
How serious is the interaction between Fenofibrate and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when starting or stopping fenofibrate and reduce the warfarin dose as needed. Continue monitoring until INR is stable.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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