Drug interactions
Fenofibric acid + Lovastatin
Severity: Moderate
Fenofibric acid and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-prescription of fenofibric acid with lovastatin may increase the risk of myopathy and rhabdomyolysis. Risk factors include advanced age, renal impairment, diabetes and high statin doses.
What this interaction means in plain words
Fenofibric acid and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibric acid belongs to Cardiovascular; Lovastatin belongs to Cardiovascular.
Why it happens
Additive muscle toxicity of the two lipid-lowering classes.
What to do
Use the lowest effective lovastatin dose and educate the patient to report unexplained muscle symptoms. Measure CK and stop treatment if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Lovastatin?
MediHelp rates the interaction as moderate. Fenofibric acid and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-prescription of fenofibric acid with lovastatin may increase the risk of myopathy and rhabdomyolysis. Risk factors include advanced age, renal impairment, diabetes and high statin doses.
How serious is the interaction between Fenofibric acid and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lovastatin dose and educate the patient to report unexplained muscle symptoms. Measure CK and stop treatment if myopathy is suspected.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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