Drug interactions
Fenofibric acid + Pravastatin
Severity: Moderate
Fenofibric acid and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid with pravastatin may add to the risk of muscle toxicity, though pharmacokinetic interaction is minimal. The combination is used when triglycerides remain elevated on a statin.
What this interaction means in plain words
Fenofibric acid and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibric acid belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity of statin and fibrate.
What to do
Use the lowest effective doses and educate the patient to report muscle symptoms. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Pravastatin?
MediHelp rates the interaction as moderate. Fenofibric acid and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibric acid with pravastatin may add to the risk of muscle toxicity, though pharmacokinetic interaction is minimal. The combination is used when triglycerides remain elevated on a statin.
How serious is the interaction between Fenofibric acid and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and educate the patient to report muscle symptoms. Check CK if symptoms develop.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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