Drug interactions
Fexofenadine + Fostamatinib
Severity: Minor
Fexofenadine and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein, which can raise plasma concentrations of fexofenadine, a P-gp substrate. Because fexofenadine has a wide safety margin, the clinical impact is usually small.
What this interaction means in plain words
Fexofenadine and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by tamatinib increases fexofenadine absorption and exposure.
What to do
No empiric dose change is needed; watch for antihistamine adverse effects such as headache or dizziness and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fexofenadine with Fostamatinib?
MediHelp rates the interaction as minor. Fexofenadine and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein, which can raise plasma concentrations of fexofenadine, a P-gp substrate. Because fexofenadine has a wide safety margin, the clinical impact is usually small.
How serious is the interaction between Fexofenadine and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; watch for antihistamine adverse effects such as headache or dizziness and reduce the dose if they occur.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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