Drug interactions
Fexofenadine + Levoketoconazole
Severity: Minor
Fexofenadine and Levoketoconazole: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises fexofenadine concentrations by inhibiting P-gp and OATP transport, and levoketoconazole is expected to behave similarly. Fexofenadine is well tolerated at higher exposure, so the effect is generally minor.
What this interaction means in plain words
Fexofenadine and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of P-gp and OATP-mediated transport of fexofenadine by levoketoconazole.
What to do
No routine dose change is required; monitor for antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Recorlev - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fexofenadine with Levoketoconazole?
MediHelp rates the interaction as minor. Fexofenadine and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole raises fexofenadine concentrations by inhibiting P-gp and OATP transport, and levoketoconazole is expected to behave similarly. Fexofenadine is well tolerated at higher exposure, so the effect is generally minor.
How serious is the interaction between Fexofenadine and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for antihistamine adverse effects.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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