Drug interactions
Fexofenadine + Loratadine
Severity: Minor
Fexofenadine and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are second-generation antihistamines, and loratadine could theoretically affect fexofenadine through P-glycoprotein. The pair is therapeutic duplication with little added benefit, but a clinically important kinetic interaction is not established.
What this interaction means in plain words
Fexofenadine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Loratadine belongs to Respiratory.
Why it happens
Possible P-glycoprotein interaction plus duplicated H1-receptor blockade.
What to do
Avoid using both antihistamines together; choose one agent. If both are taken, monitor for drowsiness or dry mouth.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexofenadine and Loratadine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Loratadine?
MediHelp rates the interaction as minor. Fexofenadine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are second-generation antihistamines, and loratadine could theoretically affect fexofenadine through P-glycoprotein. The pair is therapeutic duplication with little added benefit, but a clinically important kinetic interaction is not established.
How serious is the interaction between Fexofenadine and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both antihistamines together; choose one agent. If both are taken, monitor for drowsiness or dry mouth.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
