Drug interactions
Finerenone + Palbociclib
Severity: Moderate
Finerenone and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib, a weak CYP3A4 inhibitor, may modestly raise finerenone exposure. This can increase the risk of hyperkalemia and renal function decline.
What this interaction means in plain words
Finerenone and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Palbociclib belongs to Oncology.
Why it happens
Palbociclib inhibits CYP3A4, reducing the metabolism of finerenone.
What to do
Check serum potassium and renal function when starting or changing either drug, and adjust or hold finerenone if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Palbociclib?
MediHelp rates the interaction as moderate. Finerenone and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib, a weak CYP3A4 inhibitor, may modestly raise finerenone exposure. This can increase the risk of hyperkalemia and renal function decline.
How serious is the interaction between Finerenone and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting or changing either drug, and adjust or hold finerenone if potassium rises.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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