Drug interactions
Finerenone + Zileuton
Severity: Moderate
Finerenone and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is a weak CYP3A4 inhibitor and may raise finerenone exposure. This could increase the risk of hyperkalemia and renal effects.
What this interaction means in plain words
Finerenone and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Zileuton belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 by zileuton reduces finerenone first-pass and systemic metabolism.
What to do
Monitor serum potassium and renal function when starting or changing either drug. Adjust finerenone dose per labeling if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Zileuton?
MediHelp rates the interaction as moderate. Finerenone and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton is a weak CYP3A4 inhibitor and may raise finerenone exposure. This could increase the risk of hyperkalemia and renal effects.
How serious is the interaction between Finerenone and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when starting or changing either drug. Adjust finerenone dose per labeling if potassium rises.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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