Drug interactions
Flibanserin + Metoclopramide
Severity: Moderate
Flibanserin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin causes somnolence, dizziness and sedation, which may be additive with the CNS effects of metoclopramide. The risk of impaired alertness may therefore be increased.
What this interaction means in plain words
Flibanserin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects.
What to do
Counsel on additive drowsiness and avoid driving or hazardous activities until the response is known. Consider alternative antiemetics if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Metoclopramide?
MediHelp rates the interaction as moderate. Flibanserin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin causes somnolence, dizziness and sedation, which may be additive with the CNS effects of metoclopramide. The risk of impaired alertness may therefore be increased.
How serious is the interaction between Flibanserin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive drowsiness and avoid driving or hazardous activities until the response is known. Consider alternative antiemetics if sedation is troublesome.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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