Drug interactions
Flibanserin + Progesterone
Severity: Minor
Flibanserin and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin exposure is raised by CYP3A4 inhibitors, and progesterone has only weak inhibitory activity. Clinically relevant increases in flibanserin levels with progesterone are unlikely but cannot be excluded.
What this interaction means in plain words
Flibanserin and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flibanserin belongs to Genitourinary; Progesterone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition by progesterone may modestly raise flibanserin exposure.
What to do
No routine adjustment needed; counsel about hypotension, syncope and sedation, and avoid alcohol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Progesterone?
MediHelp rates the interaction as minor. Flibanserin and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flibanserin exposure is raised by CYP3A4 inhibitors, and progesterone has only weak inhibitory activity. Clinically relevant increases in flibanserin levels with progesterone are unlikely but cannot be excluded.
How serious is the interaction between Flibanserin and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; counsel about hypotension, syncope and sedation, and avoid alcohol.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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