Drug interactions
Flibanserin + Ticlopidine
Severity: Major
Flibanserin and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine is a strong CYP2C19 inhibitor and also weakly inhibits CYP3A4, and flibanserin is metabolized by both CYP3A4 and CYP2C19. Higher flibanserin exposure can cause hypotension, syncope and CNS depression.
What this interaction means in plain words
Flibanserin and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flibanserin belongs to Genitourinary; Ticlopidine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19 and CYP3A4 by ticlopidine reduces flibanserin clearance.
What to do
Avoid the combination if possible; flibanserin labeling advises caution with strong CYP2C19 inhibitors. If used, monitor closely for hypotension, syncope and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Ticlopidine
Frequently asked questions
Can I take Flibanserin with Ticlopidine?
MediHelp rates the interaction as major. Flibanserin and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine is a strong CYP2C19 inhibitor and also weakly inhibits CYP3A4, and flibanserin is metabolized by both CYP3A4 and CYP2C19. Higher flibanserin exposure can cause hypotension, syncope and CNS depression.
How serious is the interaction between Flibanserin and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; flibanserin labeling advises caution with strong CYP2C19 inhibitors. If used, monitor closely for hypotension, syncope and sedation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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