Drug interactions
Fluconazole + Goserelin
Severity: Moderate
Fluconazole and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Goserelin, a GnRH agonist used for androgen deprivation, can prolong the QT interval. Fluconazole also has QT-prolonging potential, so combined use may add to the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Fluconazole and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Goserelin belongs to Endocrine.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects; androgen deprivation is thought to contribute to the QT effect of goserelin.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG during co-therapy in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Fluconazole with Goserelin?
MediHelp rates the interaction as moderate. Fluconazole and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Goserelin, a GnRH agonist used for androgen deprivation, can prolong the QT interval. Fluconazole also has QT-prolonging potential, so combined use may add to the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Fluconazole and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG during co-therapy in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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