Drug interactions
Fluconazole + Lacosamide
Severity: Minor
Fluconazole and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19 and CYP2C9, which contribute to lacosamide metabolism, so lacosamide exposure may rise modestly. This may increase dizziness, PR interval prolongation and other dose-related effects, mainly in patients with renal or hepatic impairment.
What this interaction means in plain words
Fluconazole and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Lacosamide belongs to Central Nervous System.
Why it happens
Fluconazole inhibition of CYP2C19/CYP2C9 reduces lacosamide metabolism.
What to do
Monitor for dizziness, ataxia and cardiac conduction effects, and lower the lacosamide dose if adverse effects appear, especially in organ impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Fluconazole with Lacosamide?
MediHelp rates the interaction as minor. Fluconazole and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole inhibits CYP2C19 and CYP2C9, which contribute to lacosamide metabolism, so lacosamide exposure may rise modestly. This may increase dizziness, PR interval prolongation and other dose-related effects, mainly in patients with renal or hepatic impairment.
How serious is the interaction between Fluconazole and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, ataxia and cardiac conduction effects, and lower the lacosamide dose if adverse effects appear, especially in organ impairment.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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