Drug interactions
Fluconazole + Lenvatinib
Severity: Moderate
Fluconazole and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval and fluconazole has additional QT-prolonging potential. Together they may increase the risk of ventricular arrhythmias, particularly with electrolyte disturbances.
What this interaction means in plain words
Fluconazole and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Lenvatinib belongs to Oncology.
Why it happens
Additive QTc interval prolongation.
What to do
Monitor ECG and electrolytes (potassium, magnesium, calcium) and correct abnormalities. Reassess the need for fluconazole if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Fluconazole with Lenvatinib?
MediHelp rates the interaction as moderate. Fluconazole and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval and fluconazole has additional QT-prolonging potential. Together they may increase the risk of ventricular arrhythmias, particularly with electrolyte disturbances.
How serious is the interaction between Fluconazole and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes (potassium, magnesium, calcium) and correct abnormalities. Reassess the need for fluconazole if the QTc becomes prolonged.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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