Drug interactions
Fluconazole + Levamlodipine
Severity: Moderate
Fluconazole and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase levamlodipine exposure, as seen with amlodipine and CYP3A inhibitors. This can cause greater blood pressure reduction, peripheral edema and dizziness.
What this interaction means in plain words
Fluconazole and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Levamlodipine belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of levamlodipine, raising plasma concentrations.
What to do
Monitor blood pressure and edema after fluconazole is started or stopped. Lower the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Fluconazole with Levamlodipine?
MediHelp rates the interaction as moderate. Fluconazole and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase levamlodipine exposure, as seen with amlodipine and CYP3A inhibitors. This can cause greater blood pressure reduction, peripheral edema and dizziness.
How serious is the interaction between Fluconazole and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema after fluconazole is started or stopped. Lower the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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