Drug interactions
Fluconazole + Lopinavir
Severity: Minor
Fluconazole and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir (given with ritonavir) is metabolized by CYP3A4, and fluconazole may modestly raise its concentrations. Because ritonavir already strongly inhibits CYP3A4, the added effect of fluconazole is typically small. Both agents can also prolong QT to some degree.
What this interaction means in plain words
Fluconazole and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Lopinavir belongs to Anti Virals.
Why it happens
Fluconazole inhibits CYP3A4, slightly decreasing lopinavir clearance.
What to do
No dose adjustment is usually required; monitor for lopinavir adverse effects such as GI intolerance and consider an ECG in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Fluconazole with Lopinavir?
MediHelp rates the interaction as minor. Fluconazole and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lopinavir (given with ritonavir) is metabolized by CYP3A4, and fluconazole may modestly raise its concentrations. Because ritonavir already strongly inhibits CYP3A4, the added effect of fluconazole is typically small. Both agents can also prolong QT to some degree.
How serious is the interaction between Fluconazole and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for lopinavir adverse effects such as GI intolerance and consider an ECG in patients with QT risk factors.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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