Drug interactions
Fluconazole + Methylprednisolone
Severity: Moderate
Fluconazole and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase methylprednisolone concentrations, raising the risk of corticosteroid adverse effects such as hyperglycemia, fluid retention, mood changes and adrenal suppression.
What this interaction means in plain words
Fluconazole and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Methylprednisolone belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4, reducing methylprednisolone clearance.
What to do
Monitor for corticosteroid excess and reduce the methylprednisolone dose if signs appear, especially with high-dose fluconazole or prolonged therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Methylprednisolone?
MediHelp rates the interaction as moderate. Fluconazole and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can increase methylprednisolone concentrations, raising the risk of corticosteroid adverse effects such as hyperglycemia, fluid retention, mood changes and adrenal suppression.
How serious is the interaction between Fluconazole and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and reduce the methylprednisolone dose if signs appear, especially with high-dose fluconazole or prolonged therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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