Drug interactions
Fluconazole + Omaveloxolone
Severity: Major
Fluconazole and Omaveloxolone: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase omaveloxolone exposure, raising the risk of liver enzyme elevation, nausea and other adverse effects. Omaveloxolone is cleared substantially via CYP3A4.
What this interaction means in plain words
Fluconazole and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Omaveloxolone belongs to Central Nervous System.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of omaveloxolone.
What to do
Avoid if possible; if unavoidable reduce omaveloxolone to 100 mg daily and monitor for adverse effects and liver tests, reducing further to 50 mg daily if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Fluconazole with Omaveloxolone?
MediHelp rates the interaction as major. Fluconazole and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole may increase omaveloxolone exposure, raising the risk of liver enzyme elevation, nausea and other adverse effects. Omaveloxolone is cleared substantially via CYP3A4.
How serious is the interaction between Fluconazole and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable reduce omaveloxolone to 100 mg daily and monitor for adverse effects and liver tests, reducing further to 50 mg daily if needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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