Drug interactions
Fluconazole + Ozanimod
Severity: Moderate
Fluconazole and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can reduce heart rate and affect conduction, while fluconazole prolongs the QT interval. Together they may raise the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Fluconazole and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization: ozanimod slows heart rate and fluconazole prolongs QTc.
What to do
Obtain a baseline ECG before starting ozanimod in patients taking fluconazole, and seek cardiology advice if risk factors exist. Correct electrolyte abnormalities and monitor heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Fluconazole with Ozanimod?
MediHelp rates the interaction as moderate. Fluconazole and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can reduce heart rate and affect conduction, while fluconazole prolongs the QT interval. Together they may raise the risk of arrhythmia in susceptible patients.
How serious is the interaction between Fluconazole and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod in patients taking fluconazole, and seek cardiology advice if risk factors exist. Correct electrolyte abnormalities and monitor heart rate.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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