Drug interactions
Fluconazole + Palbociclib
Severity: Moderate
Fluconazole and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a CYP3A substrate, so moderate inhibitors like fluconazole may raise its exposure. This can increase neutropenia and other adverse effects.
What this interaction means in plain words
Fluconazole and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Palbociclib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4, reducing palbociclib clearance.
What to do
Monitor blood counts closely, and reduce the palbociclib dose if neutropenia or toxicity occurs. Prefer an antifungal with less CYP3A inhibition when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Fluconazole with Palbociclib?
MediHelp rates the interaction as moderate. Fluconazole and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a CYP3A substrate, so moderate inhibitors like fluconazole may raise its exposure. This can increase neutropenia and other adverse effects.
How serious is the interaction between Fluconazole and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely, and reduce the palbociclib dose if neutropenia or toxicity occurs. Prefer an antifungal with less CYP3A inhibition when possible.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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