Drug interactions
Fluconazole + Repotrectinib
Severity: Major
Fluconazole and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is expected to increase repotrectinib exposure, which may worsen dizziness, ataxia, cognitive effects and other toxicities. Repotrectinib is cleared mainly by CYP3A4.
What this interaction means in plain words
Fluconazole and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Repotrectinib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of repotrectinib.
What to do
Avoid the combination; use a non-CYP3A4-inhibiting antifungal. Labeling advises that moderate inhibitors be stopped for 3 to 5 half-lives before starting repotrectinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Fluconazole with Repotrectinib?
MediHelp rates the interaction as major. Fluconazole and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole is expected to increase repotrectinib exposure, which may worsen dizziness, ataxia, cognitive effects and other toxicities. Repotrectinib is cleared mainly by CYP3A4.
How serious is the interaction between Fluconazole and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-CYP3A4-inhibiting antifungal. Labeling advises that moderate inhibitors be stopped for 3 to 5 half-lives before starting repotrectinib.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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