Drug interactions
Fluconazole + Risperidone
Severity: Moderate
Fluconazole and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with other risk factors. Fluconazole may also modestly raise risperidone exposure through CYP2D6 and CYP3A4 inhibition.
What this interaction means in plain words
Fluconazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus fluconazole inhibition of CYP3A4/CYP2D6 metabolism of risperidone.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and for increased antipsychotic effects, and reduce the risperidone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Fluconazole with Risperidone?
MediHelp rates the interaction as moderate. Fluconazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with other risk factors. Fluconazole may also modestly raise risperidone exposure through CYP2D6 and CYP3A4 inhibition.
How serious is the interaction between Fluconazole and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and for increased antipsychotic effects, and reduce the risperidone dose if needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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