Drug interactions
Fluconazole + Ruxolitinib
Severity: Moderate
Fluconazole and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is metabolized mainly by CYP3A4, and fluconazole raises its exposure. Higher levels can worsen cytopenias such as thrombocytopenia and neutropenia.
What this interaction means in plain words
Fluconazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Ruxolitinib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 (and CYP2C9), reducing ruxolitinib clearance.
What to do
Reduce the ruxolitinib dose per labeling when combined with fluconazole (especially above 200 mg/day). Monitor blood counts frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Fluconazole with Ruxolitinib?
MediHelp rates the interaction as moderate. Fluconazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ruxolitinib is metabolized mainly by CYP3A4, and fluconazole raises its exposure. Higher levels can worsen cytopenias such as thrombocytopenia and neutropenia.
How serious is the interaction between Fluconazole and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose per labeling when combined with fluconazole (especially above 200 mg/day). Monitor blood counts frequently.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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