Drug interactions
Fluconazole + Sevoflurane
Severity: Moderate
Fluconazole and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and fluconazole adds to this effect, which matters during anesthesia when arrhythmias are harder to manage. The risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Fluconazole and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the preoperative ECG and correct potassium and magnesium before anesthesia. Maintain continuous ECG monitoring and avoid other QT-prolonging agents perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Fluconazole with Sevoflurane?
MediHelp rates the interaction as moderate. Fluconazole and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and fluconazole adds to this effect, which matters during anesthesia when arrhythmias are harder to manage. The risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Fluconazole and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and correct potassium and magnesium before anesthesia. Maintain continuous ECG monitoring and avoid other QT-prolonging agents perioperatively.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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