Drug interactions
Fluconazole + Sotalol
Severity: Major
Fluconazole and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a potent QT-prolonging beta-blocker and fluconazole adds to this effect, raising the risk of torsades de pointes. Risk increases with renal impairment, bradycardia and hypokalemia.
What this interaction means in plain words
Fluconazole and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Sotalol belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid the combination when an alternative antifungal exists. If necessary, monitor ECG and electrolytes closely and keep potassium and magnesium replete.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Fluconazole with Sotalol?
MediHelp rates the interaction as major. Fluconazole and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a potent QT-prolonging beta-blocker and fluconazole adds to this effect, raising the risk of torsades de pointes. Risk increases with renal impairment, bradycardia and hypokalemia.
How serious is the interaction between Fluconazole and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative antifungal exists. If necessary, monitor ECG and electrolytes closely and keep potassium and magnesium replete.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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