Drug interactions
Fluconazole + Tiotropium-olodaterol
Severity: Moderate
Fluconazole and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval, particularly at higher doses or with hypokalemia. Olodaterol may contribute to this effect through its cardiac and potassium-lowering actions.
What this interaction means in plain words
Fluconazole and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with possible beta2-mediated hypokalemia.
What to do
Check ECG and electrolytes in patients with additional QT risk factors. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Fluconazole and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval, particularly at higher doses or with hypokalemia. Olodaterol may contribute to this effect through its cardiac and potassium-lowering actions.
How serious is the interaction between Fluconazole and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with additional QT risk factors. Monitor for palpitations or syncope.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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