Drug interactions
Fluconazole + Trazodone
Severity: Moderate
Fluconazole and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4, which can raise trazodone concentrations, and both drugs can prolong the QT interval. The result may be excess sedation, hypotension and arrhythmia.
What this interaction means in plain words
Fluconazole and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition reducing trazodone clearance.
What to do
Consider a lower trazodone dose and monitor sedation, blood pressure and ECG. Avoid in patients with long QT or other QT-prolonging therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Fluconazole with Trazodone?
MediHelp rates the interaction as moderate. Fluconazole and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4, which can raise trazodone concentrations, and both drugs can prolong the QT interval. The result may be excess sedation, hypotension and arrhythmia.
How serious is the interaction between Fluconazole and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower trazodone dose and monitor sedation, blood pressure and ECG. Avoid in patients with long QT or other QT-prolonging therapy.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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