Drug interactions
Fluconazole + Valbenazine
Severity: Moderate
Fluconazole and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and fluconazole may increase valbenazine's active metabolite exposure. This raises arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Fluconazole and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with fluconazole CYP3A4 inhibition possibly increasing valbenazine exposure.
What to do
Monitor ECG and correct potassium and magnesium in patients with QT risk factors. Reduce the valbenazine dose if a strong CYP3A4 inhibitor effect is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Fluconazole with Valbenazine?
MediHelp rates the interaction as moderate. Fluconazole and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and fluconazole may increase valbenazine's active metabolite exposure. This raises arrhythmia risk, especially with other risk factors.
How serious is the interaction between Fluconazole and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium in patients with QT risk factors. Reduce the valbenazine dose if a strong CYP3A4 inhibitor effect is suspected.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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