Drug interactions
Fluconazole + Zonisamide
Severity: Minor
Fluconazole and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise zonisamide concentrations and increase dose-related adverse effects such as somnolence, dizziness and cognitive slowing. The clinical effect is likely limited.
What this interaction means in plain words
Fluconazole and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Zonisamide belongs to Central Nervous System.
Why it happens
Fluconazole inhibits CYP3A4, which contributes to the metabolism of zonisamide.
What to do
Monitor for sedation, dizziness and other zonisamide adverse effects when starting or stopping fluconazole, and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Fluconazole with Zonisamide?
MediHelp rates the interaction as minor. Fluconazole and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may raise zonisamide concentrations and increase dose-related adverse effects such as somnolence, dizziness and cognitive slowing. The clinical effect is likely limited.
How serious is the interaction between Fluconazole and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other zonisamide adverse effects when starting or stopping fluconazole, and adjust the dose if needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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