Drug interactions
Fluoxetine + Givosiran
Severity: Minor
Fluoxetine and Givosiran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity and raise levels of CYP2D6 substrates. Fluoxetine is a CYP2D6 substrate but also a strong inhibitor of this enzyme, so the extra increase in exposure is likely limited. Increased fluoxetine adverse effects are possible.
What this interaction means in plain words
Fluoxetine and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing fluoxetine metabolism.
What to do
No routine dose change is needed. Monitor for increased fluoxetine adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Fluoxetine with Givosiran?
MediHelp rates the interaction as minor. Fluoxetine and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can reduce CYP2D6 activity and raise levels of CYP2D6 substrates. Fluoxetine is a CYP2D6 substrate but also a strong inhibitor of this enzyme, so the extra increase in exposure is likely limited. Increased fluoxetine adverse effects are possible.
How serious is the interaction between Fluoxetine and Givosiran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased fluoxetine adverse effects and reduce the dose if they occur.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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