Drug interactions
Fluoxetine + Rolapitant
Severity: Minor
Fluoxetine and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is metabolized in part by CYP2D6, and rolapitant is a long-lasting CYP2D6 inhibitor. Fluoxetine exposure may rise modestly, though fluoxetine itself already inhibits CYP2D6 and has a long half-life, so the added effect is usually limited.
What this interaction means in plain words
Fluoxetine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, which can slightly reduce fluoxetine metabolism.
What to do
No routine dose change is needed. Watch for increased serotonergic or other adverse effects of fluoxetine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Rolapitant?
MediHelp rates the interaction as minor. Fluoxetine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is metabolized in part by CYP2D6, and rolapitant is a long-lasting CYP2D6 inhibitor. Fluoxetine exposure may rise modestly, though fluoxetine itself already inhibits CYP2D6 and has a long half-life, so the added effect is usually limited.
How serious is the interaction between Fluoxetine and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased serotonergic or other adverse effects of fluoxetine.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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