Drug interactions
Fluphenazine + Metoclopramide
Severity: Major
Fluphenazine and Metoclopramide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is a high-potency D2 antagonist, and with metoclopramide the risk of acute dystonia, parkinsonism, tardive dyskinesia and neuroleptic malignant syndrome rises.
What this interaction means in plain words
Fluphenazine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central dopamine D2 receptor antagonism.
What to do
Avoid the combination and use ondansetron or another non-dopamine-blocking antiemetic. If unavoidable, monitor closely for extrapyramidal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Metoclopramide?
MediHelp rates the interaction as major. Fluphenazine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluphenazine is a high-potency D2 antagonist, and with metoclopramide the risk of acute dystonia, parkinsonism, tardive dyskinesia and neuroleptic malignant syndrome rises.
How serious is the interaction between Fluphenazine and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use ondansetron or another non-dopamine-blocking antiemetic. If unavoidable, monitor closely for extrapyramidal symptoms.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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