Drug interactions
Fluphenazine + Prochlorperazine
Severity: Major
Fluphenazine and Prochlorperazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are phenothiazine antipsychotics that can prolong the QT interval and cause extrapyramidal effects and sedation. Combining them raises the risk of arrhythmia and dopamine-related adverse effects without clear benefit.
What this interaction means in plain words
Fluphenazine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive potassium channel blockade and dopamine D2 antagonism.
What to do
Avoid duplicate phenothiazine therapy and use a non-dopamine-blocking antiemetic with fluphenazine. If both are needed, monitor the ECG and for extrapyramidal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Prochlorperazine?
MediHelp rates the interaction as major. Fluphenazine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are phenothiazine antipsychotics that can prolong the QT interval and cause extrapyramidal effects and sedation. Combining them raises the risk of arrhythmia and dopamine-related adverse effects without clear benefit.
How serious is the interaction between Fluphenazine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate phenothiazine therapy and use a non-dopamine-blocking antiemetic with fluphenazine. If both are needed, monitor the ECG and for extrapyramidal symptoms.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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