Drug interactions
Fluphenazine + Propofol
Severity: Moderate
Fluphenazine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine may enhance the sedative and hypotensive effects of propofol and may add to QT risk. Lower doses of anesthetic may be needed.
What this interaction means in plain words
Fluphenazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilation or alpha-blockade.
What to do
Titrate propofol cautiously to effect and monitor blood pressure, respiration and ECG during sedation or anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Propofol
Frequently asked questions
Can I take Fluphenazine with Propofol?
MediHelp rates the interaction as moderate. Fluphenazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine may enhance the sedative and hypotensive effects of propofol and may add to QT risk. Lower doses of anesthetic may be needed.
How serious is the interaction between Fluphenazine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously to effect and monitor blood pressure, respiration and ECG during sedation or anesthesia.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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