Drug interactions
Fluphenazine + Vilazodone
Severity: Moderate
Fluphenazine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone with fluphenazine, a potent dopamine antagonist, may increase the risk of neuroleptic malignant syndrome and, rarely, serotonin toxicity. Most patients tolerate the combination but the reactions can be serious.
What this interaction means in plain words
Fluphenazine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effect combined with dopamine D2 blockade, a pharmacodynamic interaction.
What to do
Monitor for hyperthermia, rigidity, autonomic instability, tremor and clonus, especially at initiation and dose increases. Discontinue both agents and provide supportive care if these develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Vilazodone?
MediHelp rates the interaction as moderate. Fluphenazine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone with fluphenazine, a potent dopamine antagonist, may increase the risk of neuroleptic malignant syndrome and, rarely, serotonin toxicity. Most patients tolerate the combination but the reactions can be serious.
How serious is the interaction between Fluphenazine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, autonomic instability, tremor and clonus, especially at initiation and dose increases. Discontinue both agents and provide supportive care if these develop.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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