Drug interactions
Flutamide + Givosiran
Severity: Moderate
Flutamide and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and CYP1A2 is the main pathway for flutamide activation and clearance. Exposure to flutamide may therefore change, with possible increases in hepatotoxicity risk.
What this interaction means in plain words
Flutamide and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran-related suppression of CYP1A2 may alter flutamide metabolism.
What to do
Monitor liver function tests regularly during combined use. Consider an alternative antiandrogen if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Flutamide with Givosiran?
MediHelp rates the interaction as moderate. Flutamide and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity, and CYP1A2 is the main pathway for flutamide activation and clearance. Exposure to flutamide may therefore change, with possible increases in hepatotoxicity risk.
How serious is the interaction between Flutamide and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly during combined use. Consider an alternative antiandrogen if liver enzymes rise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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