Drug interactions
Fluvoxamine + Glofitamab
Severity: Moderate
Fluvoxamine and Glofitamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release that can temporarily suppress CYP enzyme activity, mainly around the start of treatment and during cytokine release syndrome. Fluvoxamine is a sensitive CYP1A2 substrate, so its levels could rise and cause more adverse effects such as nausea or sedation.
What this interaction means in plain words
Fluvoxamine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP1A2 activity increases fluvoxamine exposure.
What to do
Monitor for fluvoxamine adverse effects after glofitamab doses, especially during cycle 1 or if cytokine release syndrome develops. Adjust the fluvoxamine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Fluvoxamine with Glofitamab?
MediHelp rates the interaction as moderate. Fluvoxamine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab induces cytokine release that can temporarily suppress CYP enzyme activity, mainly around the start of treatment and during cytokine release syndrome. Fluvoxamine is a sensitive CYP1A2 substrate, so its levels could rise and cause more adverse effects such as nausea or sedation.
How serious is the interaction between Fluvoxamine and Glofitamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fluvoxamine adverse effects after glofitamab doses, especially during cycle 1 or if cytokine release syndrome develops. Adjust the fluvoxamine dose if toxicity occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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