Drug interactions
Fluvoxamine + Lisdexamfetamine
Severity: Major
Fluvoxamine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin and, combined with an SSRI, may precipitate serotonin syndrome. Fluvoxamine may also inhibit CYP-mediated clearance of amphetamine.
What this interaction means in plain words
Fluvoxamine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from amphetamine-induced release and SSRI reuptake inhibition.
What to do
Start lisdexamfetamine at a low dose and titrate slowly. Monitor for agitation, tremor, hyperthermia and clonus, and stop both drugs if serotonin syndrome develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Lisdexamfetamine?
MediHelp rates the interaction as major. Fluvoxamine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphetamines increase synaptic serotonin and, combined with an SSRI, may precipitate serotonin syndrome. Fluvoxamine may also inhibit CYP-mediated clearance of amphetamine.
How serious is the interaction between Fluvoxamine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lisdexamfetamine at a low dose and titrate slowly. Monitor for agitation, tremor, hyperthermia and clonus, and stop both drugs if serotonin syndrome develops.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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