Drug interactions
Fluvoxamine + Maraviroc
Severity: Minor
Fluvoxamine and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and fluvoxamine may modestly increase its exposure. Higher levels may increase dizziness and postural hypotension.
What this interaction means in plain words
Fluvoxamine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
Weak to moderate CYP3A4 inhibition by fluvoxamine reducing maraviroc clearance.
What to do
No empirical dose change is generally needed; monitor for postural hypotension and other maraviroc adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Fluvoxamine with Maraviroc?
MediHelp rates the interaction as minor. Fluvoxamine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc is a CYP3A4 substrate, and fluvoxamine may modestly increase its exposure. Higher levels may increase dizziness and postural hypotension.
How serious is the interaction between Fluvoxamine and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally needed; monitor for postural hypotension and other maraviroc adverse effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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