Drug interactions
Fluvoxamine + Metoclopramide
Severity: Moderate
Fluvoxamine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may promote serotonin toxicity, and metoclopramide adds the risk of extrapyramidal reactions. Fluvoxamine does not strongly inhibit CYP2D6, so the main concern is pharmacodynamic.
What this interaction means in plain words
Fluvoxamine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive serotonergic effects and dopamine D2 antagonism by metoclopramide.
What to do
Use the lowest metoclopramide dose for the shortest time and monitor for serotonin syndrome and movement disorders. Discontinue metoclopramide if they develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Metoclopramide?
MediHelp rates the interaction as moderate. Fluvoxamine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may promote serotonin toxicity, and metoclopramide adds the risk of extrapyramidal reactions. Fluvoxamine does not strongly inhibit CYP2D6, so the main concern is pharmacodynamic.
How serious is the interaction between Fluvoxamine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest metoclopramide dose for the shortest time and monitor for serotonin syndrome and movement disorders. Discontinue metoclopramide if they develop.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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