Drug interactions
Fluvoxamine + Pacritinib
Severity: Moderate
Fluvoxamine and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized mainly by CYP3A4, and strong inhibitors are to be avoided because of increased exposure and QT risk. Fluvoxamine is a weaker CYP3A4 inhibitor, so the effect is likely smaller.
What this interaction means in plain words
Fluvoxamine and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Fluvoxamine inhibits CYP3A4, raising pacritinib exposure.
What to do
Monitor ECG/QTc, electrolytes, and for bleeding and diarrhea; consider an alternative antidepressant if QT is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Fluvoxamine with Pacritinib?
MediHelp rates the interaction as moderate. Fluvoxamine and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is metabolized mainly by CYP3A4, and strong inhibitors are to be avoided because of increased exposure and QT risk. Fluvoxamine is a weaker CYP3A4 inhibitor, so the effect is likely smaller.
How serious is the interaction between Fluvoxamine and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc, electrolytes, and for bleeding and diarrhea; consider an alternative antidepressant if QT is a concern.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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