Drug interactions
Fluvoxamine + Posaconazole
Severity: Moderate
Fluvoxamine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia including torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia, bradycardia or other QT-prolonging medicines.
What this interaction means in plain words
Fluvoxamine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and correct electrolyte abnormalities, then monitor the QTc during co-therapy. Switch to a lower-risk antidepressant if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Posaconazole?
MediHelp rates the interaction as moderate. Fluvoxamine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have the potential to prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia including torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia, bradycardia or other QT-prolonging medicines.
How serious is the interaction between Fluvoxamine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolyte abnormalities, then monitor the QTc during co-therapy. Switch to a lower-risk antidepressant if QTc lengthens significantly.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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