Drug interactions
Fluvoxamine + Propofol
Severity: Minor
Fluvoxamine and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is metabolized partly by CYP2B6 and mostly by glucuronidation, so fluvoxamine is unlikely to raise propofol exposure meaningfully. Any effect is theoretical.
What this interaction means in plain words
Fluvoxamine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Theoretical minor CYP2B6 inhibition by fluvoxamine.
What to do
No adjustment is needed. Titrate propofol to clinical effect as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Fluvoxamine with Propofol?
MediHelp rates the interaction as minor. Fluvoxamine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol is metabolized partly by CYP2B6 and mostly by glucuronidation, so fluvoxamine is unlikely to raise propofol exposure meaningfully. Any effect is theoretical.
How serious is the interaction between Fluvoxamine and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Titrate propofol to clinical effect as usual.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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