Drug interactions
Fluvoxamine + Teriflunomide
Severity: Minor
Fluvoxamine and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak inducer of CYP1A2 and may lower fluvoxamine concentrations, since fluvoxamine is a CYP1A2 substrate. This could reduce antidepressant or anxiolytic efficacy, although the effect is expected to be modest.
What this interaction means in plain words
Fluvoxamine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide weakly induces CYP1A2, increasing fluvoxamine clearance.
What to do
Monitor the clinical response to fluvoxamine after teriflunomide is started and adjust the dose if symptoms recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Fluvoxamine with Teriflunomide?
MediHelp rates the interaction as minor. Fluvoxamine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak inducer of CYP1A2 and may lower fluvoxamine concentrations, since fluvoxamine is a CYP1A2 substrate. This could reduce antidepressant or anxiolytic efficacy, although the effect is expected to be modest.
How serious is the interaction between Fluvoxamine and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the clinical response to fluvoxamine after teriflunomide is started and adjust the dose if symptoms recur.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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