Drug interactions
Fluvoxamine + Vilazodone
Severity: Major
Fluvoxamine and Vilazodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is both an SSRI and a 5-HT1A partial agonist, so adding fluvoxamine increases serotonergic load and the risk of serotonin syndrome. Fluvoxamine may also modestly raise vilazodone levels by inhibiting CYP3A4.
What this interaction means in plain words
Fluvoxamine and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity with possible CYP3A4 inhibition by fluvoxamine increasing vilazodone exposure.
What to do
Avoid concurrent use, and allow appropriate washout when switching between them. If it happens, stop both drugs when serotonin toxicity signs appear and provide supportive care.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Vilazodone?
MediHelp rates the interaction as major. Fluvoxamine and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilazodone is both an SSRI and a 5-HT1A partial agonist, so adding fluvoxamine increases serotonergic load and the risk of serotonin syndrome. Fluvoxamine may also modestly raise vilazodone levels by inhibiting CYP3A4.
How serious is the interaction between Fluvoxamine and Vilazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, and allow appropriate washout when switching between them. If it happens, stop both drugs when serotonin toxicity signs appear and provide supportive care.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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