Drug interactions
Fosaprepitant + Posaconazole
Severity: Minor
Fosaprepitant and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, so posaconazole may increase aprepitant concentrations. Aprepitant is generally well tolerated and a single dose is used, so the clinical impact is usually modest.
What this interaction means in plain words
Fosaprepitant and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, reducing the metabolism of aprepitant formed from fosaprepitant.
What to do
No dose change is usually needed. Monitor for aprepitant-related adverse effects such as fatigue, hiccups or hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Posaconazole?
MediHelp rates the interaction as minor. Fosaprepitant and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, so posaconazole may increase aprepitant concentrations. Aprepitant is generally well tolerated and a single dose is used, so the clinical impact is usually modest.
How serious is the interaction between Fosaprepitant and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for aprepitant-related adverse effects such as fatigue, hiccups or hypotension.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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